What is Epigenetics technical articles are geared towards epigenetic research techniques, news, and trends in the field of epigenetics, written by scientists from universities and institutions including UCLA, Hofstra, NIH, Johns Hopkins, and more.

Explore in detail new epigenetic research techniques and tips for topics like next-generation sequencing (NGS) in epigenetics, m6A RNA methylation, CRISPR/Cas9 system epigenetic editing, chromatin immunoprecipitation (ChIP) protocol optimization, and single-cell epigenomics methods.

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System for Optical Control of Mammalian Endogenous Transcription and Epigenetic States

August 26, 2013 WhatIsEpigenetics

Robust and versatile technologies that enable optical modulation of transcription in the mammalian endogenous genome have been difficult to achieve for a while. To solve this problem, scientists at the Broad Institute of MIT and Harvard developed light-inducible transcriptional effectors (LITEs) — an optogenetic two-hybrid system integrating the TALE DNA-binding domain with a light-sensitive cryptochrome 2 protein and its partner CIB1 from the Arabidopsis thaliana plant. LITEs can be customized to target many endogenous genomic loci and can be quickly [more…]

In-Depth Analysis of 42 Whole-Genome Bisulfite Sequencing Data Carried Out by Broad Institute

August 24, 2013 WhatIsEpigenetics

Scientists from Broad Institute of MIT and Harvard report in-depth analysis of 42 whole-genome bisulfite sequencing data sets across 30 diverse human cell and tissue types. This study tries to answer when, where, and how many CpGs are involved in genomic regulation. Within a normal developmental context, the scientists observed dynamic regulation for only 21.8% of autosomal CpGs, most of which are situated away from transcription start sites. These dynamic CpGs co-localize with enhancers and transcription-factor-binding sites, allowing for identification [more…]

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