Sam Keating
About Sam Keating
Sam is a biomedical researcher and science communicator who investigates epigenetic gene regulation in metabolism and diseases such as diabetes and heart disease. He writes about advances in cell biology and genome research, with a focus on emerging concepts and technologies, and a strong emphasis on distilling scientific information for a general audience. Visit his blog here.

Introducing O-GlcNAc – The Latest Addition to the Orchestra of Epigenetic Modifications

December 15, 2014 Sam Keating

Post-translational modifications are well known for their influence on protein stability, enzymatic functions, as well as protein:protein interactions. At the level of gene expression, acetylation, methylation, phosphorylation, ADP-ribosylation, ubiquitination and SUMOylation are some of the most prevalent chemical modifications that regulate transcription factors and the chromatin template (the complex of DNA and histone proteins) alike. In particular, the manifold modifications occurring on the histone proteins that closely associate with DNA are proposed to constitute a gene-regulating code (the histone code). [more…]

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