Researchers rely on high quality antibodies to perform successful chromatin immunoprecipitation (ChIP) experiments. When investigating the protein-DNA interaction of interest, valid and reliable results simply cannot be attained using nonspecific…
…and DNA damage. In their study, researchers at MCG administered HDAC inhibitors (HDACis) to mice that were receiving cisplatin. Histone deacetylase inhibition is known to augment cisplatin anti-tumor inhibition, so…
…setting. One main reason for this lies in the risks associated with GTs. For instance, gene editing is a technique that directly alters a cell’s DNA code. If this type…
…first step in gene expression where a particular strand of DNA is copied into RNA. The enzymes which remove an acetyl mark are known as HDACs. When an individual consumes…
…to memory and learning. Histone deacetylases remove acetyl groups from histones, which tightens the chromatin structure consisting of DNA and histones. By allowing the histones to wrap the DNA more…
…flies to the offspring from flies who ate a normal diet and found that, when histone methylation mark H3K27me3 was reduced, the future generations were protected from heart failure. The…
…content in the promoter regions of the neuropeptides and receptors involved in these neuroendrocrine functions. Thus, they are potential candidates for methylation-dependent alterations of the expressivity. 9 Insulin matters too…
…alterations have been studied in oncological contexts, culminating in multiple FDA-approve dcancer therapeutics (Heerboth et. al, 2014). Common epigenetic modifications include acetylation, methylation, sumoylation, alterations to chromatin structure, and, perhaps…
…to display increased repressive marks (H3K9me3, H3K27me3) and decreased active marks (H3K9ac) within their H3 ARKS motifs, which correlated with a heterochromatic remodeling of the host DNA and a lower…
…By modifying certain histones, gene activity can be altered without affecting the underlying genotype, or DNA sequence. The activation of a significant amount of genes can be triggered by epigenetic…
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