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About Adam Alonzi
Adam Alonzi is a writer, biotechnologist, futurist, documentary maker, inventor, and game programmer. He is the author of A Plank in Reason and Praying for Death: A Zombie Apocalypse. His time is consumed by unrelated hobbies and ventures. Visit his blog here.

The Epigenetics of Kidney Transplantation

March 26, 2019 Adam Alonzi

As the world’s population ages, the demand for organs and ways to optimize the transplant process will only grow. While the exact interactions between different factors must be elucidated further, it is clear that allograft rejection is partially mediated by epigenetic mechanisms such as histone acetylation, DNA methylation, and microRNAs. This framework is useful when applied to the host and the graft as well as to the immunologic and nonimmunologic reasons for rejection. At this time individualized treatment is limited [more…]

The Epigenetics of Chronic Kidney Disease

January 15, 2019 Adam Alonzi

Chronic kidney disease (CKD) affects 20 million people in the United States and an estimated 8 to 16 percent of the world’s population. It is known that anomalous DNA methylation, aberrant histone alterations, and changes to microRNA expression all contribute to its pathogenesis. These epigenetic factors are crucial to the development and proper functioning of the kidneys. The manner and extent to which these factors modulate inflammation, fibrosis, and the transition of mesenchymal to epithelial cells is still being elucidated. The [more…]

The Epigenetics of Depression

March 17, 2015 Adam Alonzi

Major depressive disorder (MDD) affects up to 17% of the world’s population. The WHO estimates it will be the second most costly disease to world governments by 2020. As devastating as it is to those who suffer from it, and to their loved ones, relatively little is known about its exact causes, and while diagnosis and treatment have advanced greatly over the past twenty years, far too many people continue to slip through the cracks (only about 50% of patients [more…]

The Epigenetics of Schizophrenia

December 8, 2014 Adam Alonzi

The nascent field of epigenetics has been helpful in elucidating upon other polygenic traits and diseases. Thus it only seems logical to apply it to the study of , a chronic and debilitating illness with a sundry of risk factors. In his widely cited 2013 article, Dr. Thomas Insel defines schizophrenia as “a collection of signs and symptoms of unknown aetiology, predominantly defined by observed signs of psychosis.” The NIMH estimates it affects 1 out of 100 people. Yet in [more…]

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