The Epigenome of Circulating Cell-Free DNA as a Biomarker of Disease

November 7, 2019 Mike Spelios

Cells are continually being generated and eliminated by our bodies in an ongoing cycle crucial for maintaining proper tissue structure and function.  The death of cells during normal tissue maintenance results in the release of intracellular DNA material into the bloodstream, where it freely circulates.  In fact, healthy individuals can have up to 100 nanograms of non-encapsulated DNA fragments floating around in every milliliter of their blood.1  Circulating cell-free DNA, or cfDNA for short, has proven quite useful in various [more…]

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