Histone Modifications – Regulators of Viral Infection

October 6, 2020 Mike Spelios

Histones are the most eminent DNA-interacting proteins.  As the primary protein constituent of chromatin, forming complexes with DNA to compact our large genome for efficient nuclear organization, histones support critical cellular processes such as transcription, DNA replication, and DNA repair through diverse post-translational modifications that regulate their interactions with DNA and other nuclear proteins.  Consequently, anomalous changes in histone epigenetics can lead down the road to assorted pathological conditions, making histone modifications and their associated modifying enzymes suitable diagnostic, prognostic, [more…]

The Epigenome of Circulating Cell-Free DNA as a Biomarker of Disease

November 7, 2019 Mike Spelios

Cells are continually being generated and eliminated by our bodies in an ongoing cycle crucial for maintaining proper tissue structure and function.  The death of cells during normal tissue maintenance results in the release of intracellular DNA material into the bloodstream, where it freely circulates.  In fact, healthy individuals can have up to 100 nanograms of non-encapsulated DNA fragments floating around in every milliliter of their blood.1  Circulating cell-free DNA, or cfDNA for short, has proven quite useful in various [more…]

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