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Exercise Linked to Epigenetic Benefits that Keep the Brain Healthy

June 21, 2016 Bailey Kirkpatrick

When was the last time you exercised? Was it yesterday, a few weeks ago… or maybe a few months ago? Well, you may want to tack on “epigenetics” to the long list of reasons why you should exercise more often. We all know exercise is beneficial, but the difficulty usually lies in trying to be motivated enough to actually do it. The CDC states that frequent physical activity is one of the most important things for your health. It can [more…]

HDAC inhibitor and epigenetic effects on memory

HDAC Inhibitor Could Sharpen Memory and Treat Cancer

December 1, 2015 Bailey Kirkpatrick

New research has found that a histone deacetylase (HDAC) inhibitor drug used to treat cancer could also help sharpen memory and improve one’s ability to learn a new language. It could even help rewire the brain and sustain neurons which could be of benefit to those suffering from Alzheimer’s and dementia. Researchers from Rutgers published a study in the Journal of Neuroscience that investigated a cancer treatment drug, RGFP966, and found that it had other positive effects that were previously [more…]

An Epigenetic Link Between Memory Loss and Epilepsy

June 30, 2015 Bailey Kirkpatrick

Researchers at the University of Alabama at Birmingham have discovered a potential epigenetic explanation for why individuals with epilepsy, particularly temporal lobe epilepsy, usually experience memory loss. They even propose a way to undo that loss of memory. Published recently in the Annals of Translational and Clinical Neurology, a group of UAB scientists believes their results could progress our understanding of numerous other disorders involving memory loss and could lead to a therapeutic approach for restoring proper memory function via [more…]

Type 2 Diabetes Mellitus and Epigenetics

April 7, 2015 Mary Vagula

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disease characterized by elevated blood sugar levels due to pancreatic beta-cell functional impairment and insulin resistance in tissues such as skeletal muscle, adipose tissue and the liver (1). Millions of people around the globe are diagnosed with diabetes, and its incidence is estimated to double by 2030. It has become one of the most challenging public health issues of 21st century and the fifth leading cause of death worldwide (2). The [more…]

Epigenetics of Sleep and DNA Methylation

The Epigenetics of Sleep: 3 Reasons to Catch More Zzz’s

March 3, 2015 Bailey Kirkpatrick

Although the mysteries surrounding sleep are still being uncovered by scientists, we do know that sleep is crucial to our daytime functioning and is vital for processes such as learning and consolidation of memories. Unfortunately, we often fail to get enough sleep even when we know how important it is. Trying to compensate for poor sleep by sleeping more on the weekends or drinking stimulants like coffee just to stay awake can actually end up doing more harm than good. [more…]

epigenetic modification histone methylation caused by binge driniking

Binge Drinking Can Lead to Harmful Epigenetic Changes

December 30, 2014 Bailey Kirkpatrick

Recent research at the University of Missouri School of Medicine sheds some light on the epigenetic changes to proteins that occur as a result of . Their results could help progress treatments for liver diseases linked to alcohol consumption. The lead author of the study and Margaret Proctor Mulligan Professor at the MU School of Medicine, Shivendra Shukla, PhD, says that “we know that chronic alcohol use is damaging to the liver, but binge drinking amplifies that damage.” Chronic liver [more…]

MethylFlash Methylated DNA Quantification Kit (Colorimetric)

Global DNA Methylation Analysis: The Best Assay You Haven’t Done Yet

July 24, 2014 Milka Rodriguez

Over the past decade significant advances have been made in methylation profiling technology allowing for highly specific and accurate information about the epigenome of various species. Because the 5mC and 5hmC modifications are widespread with possibly different functions, further insight into their distribution is important. Traditional methylation analysis methods such as mass spec, HPLC and TLC allow high accuracy but also require sophisticated equipment, are not high through-put and most importantly are expensive. Likewise more modern applications such as next [more…]

HDAC histone acetylation epigenetic drug

Do We Already Have A Drug That Could Epigenetically Erase Traumatic Memories?

June 4, 2014 Bailey Kirkpatrick

Scientists at the Virginia Commonwealth University School of Medicine discovered that the drug fingolimod, which is used to treat multiple sclerosis (MS), could potentially benefit individuals who wish to get rid of painful and traumatic memories. While MS is still not entirely understood, the disease involves a process that is immune-mediated in which the immune system attacks healthy parts of the body, namely the central nervous system – the spinal cord, brain, and optic nerves. Fingolimod, or FTY720, is a [more…]

Bones of Ancient Relatives Give Us Epigenetic Clues About Ourselves

April 30, 2014 Bailey Kirkpatrick

We already know a lot about early modern humans based on scientific evidence collected from our ancestors, gaining clues from migration patterns and remnants left abandoned for ages. However, very little is known about our prehistoric relatives, the Neanderthals and Denisovans, who lived thousands of years before us. With little evidence on hand and even smaller fragments of their DNA to spare, researchers are using epigenetics to give clues about why our archaic cousins differ from us, despite our very [more…]

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