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Potential Epigenetic Avenues for ALS Relief

June 11, 2019 Tim Barry

Amyotrophic lateral sclerosis (ALS), perhaps more commonly known as Lou Gehrig’s disease, is a devastating neurological disease that ultimately leads to death. This disease eats away at nerve cells, causing death to the motor neurons in the brain and spinal cord, resulting in the loss of muscle function and eventual paralysis and respiratory failure. ALS occurs in 2 main types: Sporadic and Familial. Sporadic ALS is the most common form, and it occurs in individuals in their late 50’s/early 60’s [more…]

What is Paleoepigenetics?

April 30, 2019 Hayley Mann

To unravel the complexities surrounding the genome, advanced technologies in genomics and epigenetics are typically necessary. Most of these tests and instruments are designed with high-quality DNA and tissue specimens in mind. Accordingly, scientists preferentially use concentrated and freshly extracted DNA to achieve the best results. Yet, some researchers do not have the luxury of working with modern DNA. This is why the field of ancient DNA (aDNA) emerged. Evolutionary biologists and anthropologists that study humans and other organisms from [more…]

Child Playing With Puzzle Pieces Epigenetics

Mouse Study Verifies Gene’s Role in Autism Via Epigenetics

March 12, 2019 Natalie Crowley

More families are living with autism today than ever before. It’s a common diagnosis with a prevalence of 1 in 59 children in the US. Despite all the efforts to understand this condition, there is still no known cause. The consensus among researchers is that autism is predominantly genetic with a few environmental factors involved. However, determining a heritable link here is complex since any number of genotypic variations could underlie autism. To better pinpoint genes that may contribute to [more…]

Researchers Modify CRISPR/Cas9 System to Target Epigenetics and Reverse Diseases

June 26, 2018 Bailey Kirkpatrick

CRISPR/Cas9 is receiving a lot of buzz as a precise gene editing tool, but did you know it may also be an epigenome editing tool? Scientists from the Salk Institute used a modified CRISPR/Cas9 technique to alter gene activity rather than altering the actual underlying gene itself. They accomplished this in mouse models with disease-associated genes, treating several different diseases including kidney disease, muscular dystrophy, and type 1 diabetes. In 2014, What is Epigenetics covered the breakthrough of CRISPR/Cas9 and [more…]

epigenetic study about bees on cocaine and drug addiction

Epigenetic Bee Study Explains Why Cocaine is So Addictive

March 27, 2018 Natalie Crowley

Bees, like humans, have been known to act…well, buzzed when given cocaine. And just like us, they can also become addicted to it…even suffer from withdrawal symptoms when the drug is taken away. It’s this similarity in altered behavior to us that makes them a great model system to study when investigating the effects of cocaine use. As it just so happens, researchers from Norway and Australia recently conducted a study using honey bees to investigate cocaine dependency. Not the [more…]

Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation

January 4, 2018 Estephany Ferrufino

Neurogenesis is a highly coordinated process with sequential waves of tightly controlled changes in gene expression. N6-Methyladenosine (m6A), is believed to play a role in the epitranscriptomic mechanism that controls mammalian cortical neurogenesis. M6A is the most abundant modification in mRNA and is found in most eukaryotic cells. It is installed by the methyltransferase complex, consisting of methyltransferase-like 3 (Mettl3) and methyltransferase-like 14 (Mettl14) as the SAM-binding sub-unit. The role of m6A modification in cancer has previously been investigated. Now, [more…]

Skipping Sleep Lowers the Body’s Protective Antioxidant Levels and Induces Epigenetic Changes

December 5, 2017 Natalie Crowley

Sleep is something that nearly all species need to survive. On a daily basis, humans need about 8 hours, dogs and cats recharge with around 12 hours, and the koala takes nearly the entire day — napping a whopping 22 hours. But unlike dogs, koalas, or most other animals, we humans don’t always get enough of our required Zzz’s. Our lives are either too busy or filled with too many distractions that keep us up at night. Sometimes sleep is [more…]

Drinking Tea Can Turn Genes On or Off in Women

June 6, 2017 Bailey Kirkpatrick

Green, black, white, oolong, and rooibos – these are all types of tea many of us have enjoyed for their power to soothe or energize. But did you know that sipping on some tea could lead to epigenetic changes in your genes, especially in those linked to cancer? A recent study supports the notion that tea might be a key player in modulating a person’s disease risk by decreasing inflammation, suppressing the growth of tumors, and influencing estrogen metabolism – [more…]

Binge Drinking as a Teen May Epigenetically Harm the Health of Future Generations

December 6, 2016 Bailey Kirkpatrick

not only harms your brain and body, but may also epigenetically impact your future children, a new study reports. Excessive drinking in adolescents could turn genes on or off in their offspring’s brain, setting them up for susceptibility to certain diseases. The study, presented at the annual Society for Neuroscience meeting on Nov. 14, 2016, suggests that repeated episodes of excessive drinking when you’re young can actually put your future children at risk for developing disorders such as anxiety, depression, [more…]

RNA Methylation Gives Epigenetic Clues to Strengthening Memory

September 20, 2016 Bailey Kirkpatrick

Memory is a complex process, one that we have only just begun to understand. Research hints that it might be possible for histone modification to degrade memory if we don’t get enough sleep or that certain epigenetic anti-cancer drugs known as HDAC inhibitors could sharpen memory. RNA methylation is an epigenetic mechanism that has been recently gained a lot of attention in the field of epigenetics. Now, scientists have discovered that the epigenetic mark found on RNA, called m6A, or [more…]

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