A new technique has been developed that is expected to advance our knowledge of numerous underlying biological processes, including those implicated in complex diseases like cancer. Using machine learning —a…
…turned to epigenetic anti-cancer drug called romidepsin, which is highly potent HDAC inhibitor. They treated mice deficient in the Shank 3 gene with a low dose of the drug for…
…kill cells to treat cancer or bacterial infection,” according to Yizhak. Professor Ruppin’s lab at Tel Aviv University is a leader in the field of GSMM, which has gained enormous…
…researchers at the German Cancer Research Center (DKFZ) have developed a method called “epigenetic analysis”. This method examines the chemical markers on the animal’s DNA to determine whether it was…
…in maternal blood, monitoring of organ transplants from donor cfDNA in the recipient’s blood, and diagnosis of cancer from tumor cfDNA in so-called “liquid biopsies”. Diseases like diabetes mellitus and…
…drug popular in cancer treatment that inhibits BRD4, and determined that the inhibition of BRD4 was effective in reversing the over-production of synapse proteins, which was an impressive find for…
…these can eventually cause chemical modifications around the genes that will turn those genes on or off over time. Additionally, in certain diseases such as cancer or Alzheimer’s, various genes…
…this epigenetic programming is genome-wide, highlighting these genes as a crucial target for future research. EZH2 has been previously demonstrated as a metabolic switch in cancer, allowing the transformation of…
…used to detect diseases like pancreatic cancer and type 2 diabetes. The team performed genome-wide DNA methylation analysis of the thyroid, heart, and brain from 10 cadavers. They were then…
…et al: Antioxidants. 2019, 8(8), 247; https://doi.org/10.3390/antiox8080247. Blaschke K et al: Nature. 2013, 500(7461):222-6. doi: 10.1038/nature12362. Remely R et al: Nutrients 2017, 9(6), 607; https://doi.org/10.3390/nu9060607. Ni Y et al: Clin Cancer Res. 2012, 18(18): 4954–4961. doi: 10.1158/1078-0432….
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