Epigenetic Insights for Targeting Alzheimer’s Disease

June 19, 2024 Natalie Crowley

The recent FDA approval of Donanemab has sparked celebration within the Alzheimer’s research community, offering significant hope by slowing cognitive decline in some patients. However, it is clear to scientists that Donanemab is not a cure, and the quest to truly halt or reverse Alzheimer’s disease (AD) remains ongoing. Donanemab works by targeting amyloid beta (Aβ) plaques, a hallmark protein buildup in AD’s pathology. While clearing these plaques marks a critical step, it may not address the root cause of [more…]

Scientists Use Machine Learning to Develop an Epigenetic Clock for Predicting Biological Age Better

February 20, 2024 Natalie Crowley

In the quest to unravel the mysteries of aging, scientists have long turned to our genetic code for answers. While machine learning models have offered insights into predicting biological age, understanding the causal factors behind aging has yet to be discovered. However, a groundbreaking study has now shed light on the hidden workings of aging by delving deep into the intricate realm of epigenetics. Scientists at Brigham and Women’s Hospital, part of Mass General Brigham, have developed an innovative “epigenetic [more…]

Preventing Skin Aging: Epigenetics-Targeted Antioxidants in Skincare

December 1, 2022 Clarissa Li

Oxidative stress and antioxidant interaction determine skin aging Oxidative stress damage of the skin, as a fundamental factor of aging, can occur early at birth and continue through one’s entire life. Skin oxidative damage results from an imbalance between reaction oxidative species (ROS) generation and antioxidant defenses, of which unfavorable consequences, such as aging, increased skin diseases, loss of collagen and elastin, increased DNA damage, high skin sensitivity, and increased skin pigmentation can occur. The symptoms are comprised of wrinkling, sagging, [more…]

Epigenetic Study Links Smoke Exposure in Early Life to Advanced Aging

October 26, 2021 Natalie Crowley

Not everyone ages gracefully. That’s true for people who don’t take care of themselves as adults, but it’s also true for someone whose health was jeopardized at a young age from contact with something harmful, like air pollution or poor diet. In particular, smoking exposure during early development has been linked with numerous adverse health conditions, and now a new study shows that it, as well as other harmful pollutants, can cause advanced biological aging. Early life, beginning in the [more…]

Epigenetic Mechanism May Promote Healthy Aging

October 29, 2019 Andrea P

Aging is one of life’s inevitable processes, and has been a hot topic for scientific research over the last few years. As we know, aging has many epigenetic factors, and can be affected by a number of different things like depression, bipolar disorder, and menopause. Generally, aging results in negative health effects due to the decreasing ability for the body to repair damage done to tissues and DNA over time. But Dr. Baris Tursun from the Max Delbrück Center for [more…]

Epigenetic Changes Due to Aging May Lead to Cancer

August 21, 2018 Tim Barry

Throughout our lives, all cells in our bodies experience a normal life cycle of growth, maturity, and death. During this time, our cells normally experience damage to DNA by normal functions of the metabolism, or exposure to certain environmental factors like UV light. Ordinarily, our body is able to repair the damage done to the DNA in order to restore healthy cell function. The older we get, the more DNA damage we experience, and if damaged DNA is unable to [more…]

Exploring the Possibility of Extending Lifespan Using Epigenetic Drift

October 3, 2017 Bailey Kirkpatrick

Nearly a century ago, researchers discovered that cutting calorie intake was actually able to extend lifespan in various animal species. Although numerous studies have been conducted since to find out exactly why reducing calories can extend lifespan, scientists have been unable to pinpoint the answer. Now, a group of investigators at the Lewis Katz School of Medicine at Temple University (LKSOM) have uncovered an explanation to the longevity conundrum, something they call “age-related methylation drift.” The senior investigator, Jean-Pierre Issa, [more…]

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