Researchers Modify CRISPR/Cas9 System to Target Epigenetics and Reverse Diseases

June 26, 2018 Bailey Kirkpatrick

CRISPR/Cas9 is receiving a lot of buzz as a precise gene editing tool, but did you know it may also be an epigenome editing tool? Scientists from the Salk Institute used a modified CRISPR/Cas9 technique to alter gene activity rather than altering the actual underlying gene itself. They accomplished this in mouse models with disease-associated genes, treating several different diseases including kidney disease, muscular dystrophy, and type 1 diabetes. In 2014, What is Epigenetics covered the breakthrough of CRISPR/Cas9 and [more…]

Cut Out the Hype: Gene Editing With CRISPR and the Truth about Superhuman ‘Designer Babies’

February 28, 2017 Bailey Kirkpatrick

Stories about a mysterious tool that can cut out and replace genes have crept out from behind the lab walls and entered boldly into the public spotlight. Nowadays, CRISPR is everywhere. And we can’t help but let our imaginations wander, especially when the questions posed by this novel gene editing technology come straight out of a sci-fi movie. Can we edit out bad genes that cause diseases in humans and replace them with healthy ones? Might parents be able to [more…]

Editing DNA Methylation Using CRISPR/Cas9

November 29, 2016 Estephany Ferrufino

Gene expression is controlled on several levels from DNA sequence to post-transcriptional changes. Epigenetics demonstrate that gene expression can be controlled by chemical changes in the DNA such as methylation. Since the discovery of epigenetics, researchers have been attempting to produce effective methods to alter the methylation status of select genes. This would enable researchers to effectively turn on or off target genes without affecting the genetic code. Liu et al. (2016) have repurposed the CRISPR/Cas9 system to edit DNA [more…]

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