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About Brandon Eudy
Brandon received his PhD in Nutritional Sciences from the University of Florida and is currently a postdoctoral scholar at the University of North Carolina at Chapel Hill. He is fascinated with the impact of nutrition on health and physiology and is ever curious about the role of epigenetics in mediating nutrient-gene interactions. Outside of the lab, Brandon enjoys lifting weights, learning about the latest tech, and honing his cooking skills.

Histone Deacetylases Play a Role in Health & Renewal of Intestinal Barrier

September 1, 2020 Brandon Eudy

The barrier of the small intestine consists of a thin layer of cells which blocks pathogens from entering the body and has a major role in absorbing nutrients through microvilli. Maintenance of the intestinal barrier is important since these cells are constantly being sloughed off as food passes through and tiny amounts of damage can cause a leaky gut which is now understood to be associated with several chronic diseases (Fasano 2017 and Meddings 2006). The intestinal barrier is normally [more…]

Parenteral Nutrition May Alter Epigenetic Marks in Infant Guinea Pigs

August 4, 2020 Brandon Eudy

Parenteral nutrition (PN) is a means of administering intravenous nutrition to critically ill patients or individuals who cannot otherwise consume food through the normal oral route. Although PN is a critical part of patient care in many clinical situations, it must be carefully administered to avoid harmful side effects. Infants may be especially vulnerable to complications caused by receiving suboptimal PN due to having specific nutrient requirements for growth and development. One other concern with PN mixtures is that they [more…]

Betaine Intake During Pregnancy May Epigenetically Effect Transcription

May 26, 2020 Brandon Eudy

Betaine is a methyl-donor nutrient that can be obtained through the diet and is especially rich in spinach, beets, and whole-wheat foods. Alternatively, betaine can be synthesized from choline obtained through other dietary sources. Methyl donor nutrients provide precursors for methyl groups used in important biological processes including methyltransferase enzymes which regulate DNA methylation. There is currently great interest in better understanding how dietary methyl donors can effect epigenetics, and whether changes in DNA methylation can be carried from generation [more…]

Epigenetic Marks May Regulate Liver Disease

April 21, 2020 Brandon Eudy

Nonalcoholic fatty liver disease (NAFLD) is an increasingly alarming health problem in the United States where it is estimated that up to 30% of the population has a fatty liver. Approximately 10% of NAFLD patients will progress in disease severity leading to inflammation and fibrosis and eventually more serious consequences such as cirrhosis or liver cancer. Better understanding the molecular and epigenetic changes in the liver driving disease progression could lead to better treatments. Understanding how DNA methylation is altered [more…]

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