Aging is a normal process linked to specific patterns and changes in the epigenome, particularly DNA methylation. Harnessing epigenetic mechanisms and understanding the epigenetic clock might enable us to slow or reduce human aging in the future, especially as scientific research reveals new associations and insights.

After DNA methylation patterns have been established during embryogenesis, researchers investigate how they are maintained, and how the environment can influence changes to marks on top of DNA during one’s lifespan.

Accurately Telling the Age of Human Tissues and Cells by DNA Methylation Clock

November 11, 2013 WhatIsEpigenetics

External signs of the human body’s age can be given by wrinkles and graying hair. However, these signs may not be accurate to tell the age of human tissues and cells that construct your body. Geneticist and biomathematician Steve Horvath at the University of California Los Angeles has developed a multi-tissue predictor of age that enables one to estimate the age of most tissues and cell types based on DNA methylation that can selectively switch off genes. This age predictor was [more…]

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