Articles that explore the connection between epigenetics and diseases and disorders, including cancer, cardiovascular disease, diabetes, autoimmune disease, and more.

Chromatin Immunoprecipitation Study Supports HDAC Inhibitor as Possible Lung Cancer Treatment

July 28, 2015 Bailey Kirkpatrick

A person’s genetic code can contribute to their risk for developing non-small cell lung cancer (NSCLC), which accounts for about 85% of lung cancers. Epigenetics, the study of chemical tags that impact gene expression without altering the genetic sequence, is shown to also profoundly influence the development of cancer. In a study by Asan Medical Center researchers from The University of Ulsan College of Medicine in Korea, chromatin immunoprecipitation (ChIP)-on-chip assays and other techniques were used to investigate the epigenetic [more…]

New Research Sheds Light on the Epigenetics of Common Variable Immunodeficiency

July 21, 2015 Bailey Kirkpatrick

For the very first time, epigenetic alterations have been linked to common variable immunodeficiency (CVID), the most commonly diagnosed primary immunodeficiency that leads to a decrease in antibodies and an increase in developing an infection. Scientists at the Bellvitge Biomedical Research Institute (IDIBELL) and La Paz Hospital (IDIPAZ) in Spain looked at monozygotic twins and measured epigenetic differences, specifically DNA methylation levels, between one twin with CVID and the other without the disease. The group of researchers, directed by Dr. [more…]

An Epigenetic Link Between Memory Loss and Epilepsy

June 30, 2015 Bailey Kirkpatrick

Researchers at the University of Alabama at Birmingham have discovered a potential epigenetic explanation for why individuals with epilepsy, particularly temporal lobe epilepsy, usually experience memory loss. They even propose a way to undo that loss of memory. Published recently in the Annals of Translational and Clinical Neurology, a group of UAB scientists believes their results could progress our understanding of numerous other disorders involving memory loss and could lead to a therapeutic approach for restoring proper memory function via [more…]

Smoking Linked to Epigenetic Warning Signs of Cancer in Cheek Cells

May 26, 2015 Bailey Kirkpatrick

New research published in JAMA Oncology shows that DNA damage that occurs as a result of smoking may be found in cheek swabs. In light of this research, smoking is thought to adjust the epigenetic profile of cheek cells and the resulting epigenetic landscape may even be used as an early warning sign of other cancers typically unrelated to smoking, such as gynecological and breast cancers. Professor Martin Widschwendter, Head of the Department of Women’s Cancer at the UCL Institute [more…]

DNA Methylation and Glucocorticoid Resistance Offers Clues to Improve Cancer Drugs

May 12, 2015 Bailey Kirkpatrick

Scientists from St. Jude Children’s Research Hospital conducted a study that illuminates a mechanism by which leukemia cells resist steroids, a key factor detrimental to the success of chemotherapy. This discovery could help create more effective cancer drugs and improve the treatment of many autoimmune related diseases. The researchers looked at a certain type of steroid hormones involved in the immune system, known as glucocorticoids. These hormones are crucial components to the chemotherapy drug cocktail that has helped increase long-term [more…]

Can An Infection Alter Your Epigenome?

May 5, 2015 Bill Sullivan

There are many examples of infectious agents that are capable of modifying the behavior of their host organism. Pathogens typically co-opt their host in ways that create an opportunity to spread into another host. For example, the rabies virus is transmitted through saliva, so the virus transforms its host into an unusually aggressive beast that is prone to bite other animals. The single-celled parasite known as Toxoplasma gondii is another clever puppeteer of its host. Rodents infected with this microbe [more…]

How Eating Zinc Could Affect DNA Methylation and the Immune System

April 28, 2015 Bailey Kirkpatrick

Zinc is a mineral that’s vital to our health and is involved in several aspects of cellular metabolism. According to the National Institutes of Health, zinc plays a role in a wide range of important processes like healing wounds, synthesizing proteins and DNA, and the division of cells. It’s even required to be able to taste and smell properly. Published in Molecular Nutrition & Food Research, recent evidence conducted at the Oregon State University also suggests that zinc affects the [more…]

Type 2 Diabetes Mellitus and Epigenetics

April 7, 2015 Mary Vagula

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disease characterized by elevated blood sugar levels due to pancreatic beta-cell functional impairment and insulin resistance in tissues such as skeletal muscle, adipose tissue and the liver (1). Millions of people around the globe are diagnosed with diabetes, and its incidence is estimated to double by 2030. It has become one of the most challenging public health issues of 21st century and the fifth leading cause of death worldwide (2). The [more…]

Could Epigenetics Explain the Origins of Allergic Disease?

March 24, 2015 Natalie Crowley

Finally, spring is here – that wonderful time of year when the temperature starts to rise and everything is in bloom. But for many of us, it also marks the beginning of allergy season. That means itchy watery eyes, sneezing, running nose, coughing and overall misery. But allergies don’t just affect people in the spring and they are not all related to weather. According to the Centers for Disease Control and Prevention (1), more than 50 million Americans have an allergy [more…]

The Epigenetics of Depression

March 17, 2015 Adam Alonzi

Major depressive disorder (MDD) affects up to 17% of the world’s population. The WHO estimates it will be the second most costly disease to world governments by 2020. As devastating as it is to those who suffer from it, and to their loved ones, relatively little is known about its exact causes, and while diagnosis and treatment have advanced greatly over the past twenty years, far too many people continue to slip through the cracks (only about 50% of patients [more…]

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