Vitamin C Modulates TET1 Function During Somatic Cell Reprogramming

November 1, 2013 Milka Rodriguez

Cellular reprogramming of somatic cells to a pluripotent state (an undetermined state in which a cell is capable of differentiating to all of the various cell types of the body) is accompanied by several epigenetic changes including genome-wide resetting of DNA methylation status. Vitamin C, an essential nutrient for humans, is involved in several metabolic pathways and in the prevention of conditions such as scurvy. Vitamin C was recently found to promote the generation of induced pluripotent stem cells (iPSCs) [more…]

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