Bisphenol A Can Reprogram Liver’s Epigenome and Result in Disease in Rats

July 7, 2020 Sadman Sakib

There has been growing literature that suggests how environmental chemical exposure can lead to birth defects but the majority of the studies are association based. A fraction of those studies have shown how ambient chemical exposure affects insulin sensitivity and lipid metabolism1  or affecting gut-microbiota2. But how early life chemical exposure can affect epigenetics—or change the epigenome and drive the effect till later life was missing. A new study published recently in Nature Communication by Dr. Lindsey Treviño and her [more…]

Epigenetic Marks May Regulate Liver Disease

April 21, 2020 Brandon Eudy

Nonalcoholic fatty liver disease (NAFLD) is an increasingly alarming health problem in the United States where it is estimated that up to 30% of the population has a fatty liver. Approximately 10% of NAFLD patients will progress in disease severity leading to inflammation and fibrosis and eventually more serious consequences such as cirrhosis or liver cancer. Better understanding the molecular and epigenetic changes in the liver driving disease progression could lead to better treatments. Understanding how DNA methylation is altered [more…]

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