The Epigenetics of Kidney Transplantation
As the world’s population ages, the demand for organs and ways to optimize the transplant process will only grow. While the exact interactions between different factors must be elucidated further, it is clear that allograft rejection is partially mediated by epigenetic mechanisms such as histone acetylation, DNA methylation, and microRNAs. This framework is useful when applied to the host and the graft as well as to the immunologic and nonimmunologic reasons for rejection. At this time individualized treatment is limited [more…]
