The Epigenetic Landscape is a Key Determinant of Gene Expression Reprogramming in Cardiac Hypertrophy

12 years ago

The epigenetic signature for cardiac hypertrophy, which can progress to heart failure through an adaptive response of the myocardium to…

Transposase-Accessible Chromatin Assay for Fast and Sensitive Epigenomic Profiling

12 years ago

Scientists at Stanford University School of Medicine have developed a rapid and sensitive method for integrative epigenomic analysis called assay…

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

12 years ago

Circadian rhythms are the physiological changes that follow a roughly 24-hour cycle, such as the sleep-wake cycle. They are found…

Accurately Telling the Age of Human Tissues and Cells by DNA Methylation Clock

12 years ago

External signs of the human body’s age can be given by wrinkles and graying hair. However, these signs may not…

Vitamin C Modulates TET1 Function During Somatic Cell Reprogramming

12 years ago

Cellular reprogramming of somatic cells to a pluripotent state (an undetermined state in which a cell is capable of differentiating…

Simple Blood Test of DNA Methylation Markers Promises Early Diagnosis of Pancreatic Cancer

12 years ago

The scientists at Johns Hopkins University used a genome-wide pharmacologic transcriptome approach to identify two novel cancer-specific DNA methylation markers…

New Technique Available to Measure m6A Levels for RNA Methylation Studies

12 years ago

Researchers at Epigentek recently developed a new and breakthrough approach to identify the "fifth base" of RNA, N6-methyladenosine (m6A) to…

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

12 years ago

The scientists at MIT describe an approach for efficient targeted demethylation of specific CpGs in human cells using fusions of…

DNMT1-Interacting RNAs Block Gene-Specific DNA Methylation

12 years ago

5-methylcytosine is found in the context of paired symmetrical methylation of a CpG site. In normal somatic cells, most CpG…

A New Study Shows MicroRNA-26a Targets DNA Demethylation Enzymes

12 years ago

In their studies, the scientists at Beckman Research Institute of City of Hope demonstrated that Ten eleven translocation (TET) enzymes…