Synergistic Epigenetic Medications Show Promise in Colorectal Cancer and Beyond

July 12, 2024 Natalie Crowley

Colorectal cancer ranks as the second leading cause of cancer-related deaths in the United States, presenting a multifaceted challenge influenced by both genetic and environmental factors. Despite advancements in treatment, there remains a pressing need for innovative therapies, particularly as cases rise among younger adults and at advanced disease stages. One promising approach lies in epigenetics, the study of chemical modifications on DNA and its packaging proteins that influence gene expression without altering the DNA sequence. Cancer cells often display [more…]

Reversing Fate: Exploiting Epigenetics to Treat Drug Resistance in Cancer

June 27, 2023 Pamela A. Harvey

All cancerous tumors exhibit these reversible epigenetic changes that could represent novel reprogrammable targets to address drug resistance (1). Recent research published in Communications Biology provides essential information about the specific epigenetic alterations that may be responsible for chemotherapy resistance (2). Drug Resistance in Cancer More than 90% of the mortality caused by cancer can be linked to drug resistance (3). The molecular mechanisms mediating drug resistance in cancerous cells include increased function of enzymes that render drugs ineffective, mutations [more…]

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