Exposure to Chemicals in Plastics During Development Could Increase the Risk of Autism and Dementia

May 30, 2023 Pamela A. Harvey

Associations between prenatal exposure to chemicals like endocrine disruptors found in plastics and the development of neurological diseases later in life have been well described (1). Although mechanisms have been proposed for how endocrine disruptors affect human health (2), those mediating the development of neurological conditions like autism and dementia have been difficult to elucidate because of the multifactorial nature of these diseases. Researchers, therefore, considered the issue through a new lens: inherited  DNA methylation patterns. Bisphenols and phthalates are [more…]

Epigenetic Biomarkers May Help Assess a Father’s Likelihood of Having an Autistic Child

March 16, 2021 Natalie Crowley

Autism rates have risen steadily in the past two decades, now affecting an estimated 1 in 54 children in the US. Efforts to better understand this condition and treat it effectively have risen, too. However, the underlying causes of autism spectrum disorder (ASD) remain unclear, and there is no known preventative measure or cure. But with research on the rise, scientists are coming closer to some answers. For one, ASD appears to be primarily related to the father’s transmission. While [more…]

The Epigenetics of Autism Spectrum Disorder (ASD)

August 27, 2019 Laurel Fish

Autism spectrum disorder (ASD) comprises of a range of neurodevelopmental disorders characterised by social/communication deficits as well as repetitive/restrictive interests or behaviours. Currently, the exact causes of ASD symptomology is far from being understood. This is, in part, due to the complex and multifactorial nature of the disorder. Despite such complexities significant progress to understanding the disorder has been made over the past few decades. Currently, it is speculated that a combination of genetic susceptibility (such as possessing rare or [more…]

Social Deficits of Autism Reversed By Epigenetic Drug

July 31, 2018 Tim Barry

It is estimated that 1 in 59 children in the United States fall somewhere on the autism spectrum. Autism spectrum disorder  (ASD) is a developmental disorder that affects the nervous system and is characterized by challenges with speech, social skills and communication.  Many factors can determine a child’s predisposition to developing autism, such as genetic mutations during brain development, chemical imbalance, and certain genetic disorders like tuberous sclerosis  and fragile X syndrome. Autism has been an incredibly difficult disease to [more…]

Epigenetic Reprogramming Gone Awry in Embryo May Lead to Abnormal Adult Behavior

February 16, 2016 Bailey Kirkpatrick

Epigenetic reprogramming occurs to the developing mammalian zygote immediately after fertilization and is crucial for proper development. This reprogramming is defined as the erasure of epigenetic marks such as DNA methylation and histone modifications. Researchers continue to uncover new information about the changes made to epigenetic marks on the embryo’s epigenome. In fact, a new study has found that when the process of epigenetic reprogramming goes awry, it can have severe consequences later in development, for instance, leading to abnormal [more…]

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