Cancer Genes May Have Been Epigenetically Silenced Over Time

August 6, 2019 Andrea P

The factors contributing to the development of cancer in an individual are often complex and varied. Sometimes they are more straightforward, like when someone carries a specific gene known to indicate cancer risk; for example, specific mutations of BRCA1 or BRCA2 are linked to breast cancer. But usually, these risk factors are not so directly observable, making cancer risk detection—and possibly even cancer prevention—difficult. Any insights into what leads into the development of cancer are therefore critical. It’s not just [more…]

How Shutting Down DNA Methylation Affects the “Dark Matter” in Our Genome

July 30, 2019 Natalie Crowley

Along the vast stretches of molecules that make up our DNA, only a small portion (about 3%) consists of genes, the essential building blocks or our bodies. The rest has been considered dark matter, as it appears to serve little to no biological purpose. Out of this area, the most substantial bulk is comprised of mobile genetic elements that scientists call transposons or transposable elements (TEs). Throughout evolution, these TEs have colonized our genome by basically copying and pasting themselves [more…]

Epigenome Map of Cell May Help Show Cancer Evolution & Drug Resistance

May 28, 2019 Tom Owens

Due to its widespread impact across various developed countries and cultures, cancer has been the focus of an ever-increasing number of studies worldwide. What makes these studies difficult, however, is the complicated nature of how cells become cancerous and/or malignant, and further is the overwhelming amount of diversity of the kinds of diseases that all fall under the umbrella of “cancer.” Scientists have made headway in studying the various genetic mutations that occur in cancer cells which make them behave [more…]

Epigenetic Drugs That Fight Cancer Also Show Promise as Antivirals

October 31, 2017 Bailey Kirkpatrick

Epigenetic drugs designed to fight cancer might actually be used against many viruses as well. A recent study published in the American Society for Microbiology shows that some pharmaceuticals that act epigenetically have the power to be used as broad spectrum antivirals. Specifically, the researchers looked at histone methyltransferases EZH2/1 inhibitors which can help fight against cancer. Numerous DNA viruses, such as herpes simplex virus (HSV), are involved in epigenetic regulation which determines productive infection, persistence, and latency. Modulation to [more…]

‘Magical’ Mushroom Could Fight off Cancer with Epigenetics

August 16, 2017 Bailey Kirkpatrick

A certain type of mushroom might epigenetically prevent tumor growth, according to a study published in the Journal of Cancer Research and Treatment. A medicinal mushroom, Phellinus linteus (PL), could come with “magical” anticancer properties. Researchers from New York Medical College found that histone deacetylase (HDAC) inactivation and histone acetylation led to the death of bladder cancer cells. Chemotherapy and immunotherapy often come with severe side effects, and for those suffering from bladder cancer, the use of these therapies is [more…]

Casticin Found Naturally in Fruits May Epigenetically Fight Off Stomach Cancer

April 25, 2017 Bailey Kirkpatrick

Casticin, a type of flavonoid, could adjust chemical tags on DNA to stave off gastric cancer, a recent study suggests. Found in wormwood and various fruits, including chasteberry and oil from the chaste tree, casticin is able to epigenetically impact the expression of a gene that inhibits stomach cancer. Although additional research and clinical studies are needed, the results hint that consuming a naturally occurring plant compound might fight tumor growth. Gastric cancer, often caused by an infection from H. [more…]

Histone Deacetylation Turns Cancer-Protecting Cells into Cancer-Killing Cells

September 29, 2015 Bailey Kirkpatrick

A significant advancement in cancer research was presented in a recent study conducted by scientists from Cornell University, University of Chicago, and Houston Methodist Hospital. The researchers demonstrated that a specific protein known as a cell surface receptor can cause immune cells to attack malignant tumors as opposed to protecting them via an epigenetic mechanism known as histone deacetylation. The research was published in Nature Communications. CD4+ T-cells, also known as CD4 or helper T-cells, are crucial to the immune [more…]

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