Histone Modifications
…control or regulate DNA methylation through chromatin-dependent transcriptional repression or activation. In the cell nucleus, when histone methylation occurs, specific genes within the DNA complexed with the histone may be…
Search Results for dna methylation
Paternal Exercise Epigenetically Enhances Expression and Inheritance of a Key Gene Involved in Learning and Memory
…and histone acetylation as having opposing effects: DNA methylation represses gene expression, while histone acetylation promotes gene expression. A class of enzymes called DNA methyltransferases (DNMTs) catalyzes methylation of DNA…
DNA Methylation Gives Epigenetic Hope to Cocaine Addiction Treatment
…DNA in this way. Specifically, RG108 is known as a DNA methyltransferase (DNMT) inhibitor that interacts with DNMT to inhibit DNA methylation. Cocaine addiction in a rat model The researchers…
Mitochondrial DNA Methylation Gives Clues to Insulin Response in Pre-Diabetics
…developing type 2 diabetes, who do not respond to insulin had altered DNA in their mitochondria and had an increased amount of DNA methylation in a region that controls the…
Novel Assay to Probe the DNA Methylation State of Multiple Genomic Loci in Single Cells
The scientists from A*STAR’s Institute of Medical Biology (IMB) and Institute of Molecular and Cell Biology (IMCB) developed a novel methodology to probe single cells for various DNA-methylation errors at…
DNA Methylation Could Explain How People Respond to Fear and Anger
…and angry faces. By bisulfite converting the DNA and pyrosequencing, the researchers were able to find a link between the level of DNA methylation of a person’s oxytocin receptor gene…
DNA Methylation Study Provides Insight for Treating Brain Cancer
…on DNA methylation and the role that this particular epigenetic mechanism plays in the progression of glioblastoma. DNA methylation is an epigenetic modification that occurs when a methyl group is…
Epigenetic Changes Due to Aging May Lead to Cancer
…groups over time. Stochastic (random) DNA methylation occurs during tumorigenesis compared to Programmed DNA metylation during senescence. Black circles indicate methylation sites, white circles indicate areas of no methylation….
Most Dangerous Lifestyle Activity Uncovered in New Epigenetic Mortality Risk Profile
…and the Helmholtz Research Center for Environmental Health in Munich investigated DNA methylation and what it reveals about someone’s health and his or her mortality risk. DNA methylation is one…
Does DNA Methyltransferase Control the Brain’s ‘Gender’?
…level of DNA methylation via whole-genome bisulfite sequencing. They reported that gonadal steroids in this particular area “reduce activity of DNA methyltransferase (Dnmt) enzymes, thereby decreasing DNA methylation and releasing…
