Mike Spelios

DNA Methylation Editing: Expert Insights into the Technologies, Challenges, and Future Perspectives

This article was first published by EpigenTek. Since the 1970s when studies on the epigenetics of chromatin first started, histone and…

4 months ago

Therapeutic Targeting of Histone Modifications: Insights from the Experts

This article was first published by EpigenTek. It would be a near impossible feat for the human genome, consisting of…

8 months ago

Histone mimicry: How a SARS-CoV-2 protein functions as an H3 mimic to disrupt host cell epigenetic regulation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first recognized at the beginning of 2020 and is responsible for the…

1 year ago

m6A Editing: Harnessing CRISPR-Cas for Programmable RNA Modification

“The fifth RNA base” N6-methyladenosine, or m6A, is the most common and abundant eukaryotic RNA modification, accounting for over 80%…

1 year ago

Accessing Histone PTMs: Insights Into the Methods Used for Their Assessment

This article was first published by EpigenTek. In the early 1960s, Vincent G. Allfrey and his colleagues at the Rockefeller…

2 years ago

Living in a dreamworld: What genetics (and epigenetics?) can tell us about lucid dreams

Have you ever become aware that you’re in a dream state while you’re dreaming?  If so, then chances are you’ve…

2 years ago

Histone Modifications – Regulators of Viral Infection

Histones are the most eminent DNA-interacting proteins.  As the primary protein constituent of chromatin, forming complexes with DNA to compact…

4 years ago

The Epigenome of Circulating Cell-Free DNA as a Biomarker of Disease

Cells are continually being generated and eliminated by our bodies in an ongoing cycle crucial for maintaining proper tissue structure…

4 years ago