Reversing Fate: Exploiting Epigenetics to Treat Drug Resistance in Cancer
All cancerous tumors exhibit these reversible epigenetic changes that could represent novel reprogrammable targets to address drug resistance (1). Recent research published in Communications Biology provides essential information about the specific epigenetic alterations that may be responsible for chemotherapy resistance (2). Drug Resistance in Cancer More than 90% of the mortality caused by cancer can be linked to drug resistance (3). The molecular mechanisms mediating drug resistance in cancerous cells include increased function of enzymes that render drugs ineffective, mutations [more…]
