News & Reviews Archives | Page 7 of 38

Using CRISPR/Cas9 to Epigenetically Activate or Deactivate Genes

December 7, 2021 Natalie Crowley

Since the discovery of the CRISPR-Cas9 system, targeting DNA more precisely for genetic editing has become a lot easier. However, removing part of the genetic code may not be necessary in all cases, especially if there were a way to switch off a gene of interest instead. Thankfully, scientists have found that CRISPR/Cas9 can also be used to do just this – deactivate genes without altering the underlying DNA sequence. When we refer to a cell’s DNA, we’re actually talking [more…]

Scientists Epigenetically Rejuvenate Aging Bone Marrow Stem Cells

November 23, 2021 Natalie Crowley

Most people don’t think about their bones until maybe they break one. But breaking a bone, especially when you are older, could signify that your bones are weak. As we age, our bones become thinner, and our risk for diseases like osteoporosis is higher. This is because the stem cells responsible for keeping bone tissue dense and strong become impaired as we age. Research over the past few years has shown that aging is a process that involves epigenetic factors, [more…]

Epigenetic Study Links Smoke Exposure in Early Life to Advanced Aging

October 26, 2021 Natalie Crowley

Not everyone ages gracefully. That’s true for people who don’t take care of themselves as adults, but it’s also true for someone whose health was jeopardized at a young age from contact with something harmful, like air pollution or poor diet. In particular, smoking exposure during early development has been linked with numerous adverse health conditions, and now a new study shows that it, as well as other harmful pollutants, can cause advanced biological aging. Early life, beginning in the [more…]

Mapping the Epigenome for Pain Relief

October 12, 2021 Natalie Crowley

There are a lot of medications and techniques available for relieving pain today, but getting the right ones that work best for a patient is still challenging. First and foremost, a physician needs an accurate description of the pain to help treat it. However, communicating the location and intensity of pain isn’t that straightforward for many patients, even when asked detailed questions. That’s because pain symptoms are unique to each person and subjective. What may be considered unbearable to one [more…]

How Inflammation Epigenetically Primes Epithelial Cells to Promote Pancreatic Cancer

September 28, 2021 Natalie Crowley

Pancreatic cancer may not be as common as some cancers, but it has a bad reputation for being highly fatal, especially since it’s difficult to detect early. Smoking, diabetes, family history, and alcohol abuse are among the top risk factors associated with this disease. While it’s difficult to determine the exact causes of pancreatic cancer, a key mediator in its development is inflammation. Understanding why inflammation might lead to tumor growth in the pancreas has scientists examining the underlying mechanisms [more…]

Exercise Training Epigenetically Benefits Overall Health

September 14, 2021 Natalie Crowley

There’s no question that exercise is good for you, not only for developing a great physique but for overall health. Some would even say that regular exercise, combined with proper nutrition, is better at preventing and treating certain diseases than many pharmacological interventions. Even so, medical experts are still trying to determine exactly how physical fitness affects the chemical make-up of the body, especially regarding how it reduces the risks of developing chronic illnesses like cancer, cardiovascular disease, diabetes, and [more…]

Predicting Schizophrenia Risk Based on Epigenetics

August 31, 2021 Natalie Crowley

Schizophrenia is a complex and severe mental illness that affects approximately 1% of the global population. Often misdiagnosed for symptoms similar to other cognitive disorders, this condition lacks a valid biochemical laboratory test to support its clinical diagnosis. Studies have shown that schizophrenia has both genetic and environmental components, suggesting that epigenetic dysregulation is likely an important contributor to its etiology. Thus, developing a diagnostic tool that can identify these abnormal epigenetic modifications could help detect the disease properly and [more…]

A Stimulating Environment May Prevent The Brain From Epigenetically Aging

August 17, 2021 Natalie Crowley

One unfortunate side effect of aging is loss of brain function. For most people, it starts off here and there with some “forgetfulness” or a modest decline in other thinking skills. But brain loss can be progressive as we age and lead to more problematic conditions such as dementia or Alzheimer’s. One possible key to maintaining brain functioning and staying sharp-minded could be as simple as living a varied and active life. While this notion isn’t new, current research is [more…]

Epigenetic Alteration Linked To Lung Cancer Relapse

August 3, 2021 Natalie Crowley

Chemotherapy has been the mainstay for lung cancer treatment for decades. Unfortunately, even after an initial positive response to it, tumors can sometimes develop drug resistance. When this happens, there is little doctors can do to improve a patient’s outcome, as the survival rate after relapse can be devastatingly low. Understanding exactly what causes this cancer to rebound has scientists taking a closer look at the genetic diversity of lung tumors, in particular their epigenetic signature. In recent years, genomic [more…]

Scientists Study How Selective Mating in Nematodes Can Result in Permanent Epigenetic Changes

July 20, 2021 Natalie Crowley

If the study of epigenetics has taught us anything, it’s that we can no longer blame our entire biological inheritance solely on our DNA. Part of that blame can be traced back to the environment that our parents or grandparents were exposed to during their lifetime. Alterations in their epigenetic profile that resulted from these exposures have the potential to be passed on to descendants. Researchers call this phenomenon epigenetic heredity, and it explains how certain stimuli such as diet, toxins, [more…]

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