In-Depth Analysis of 42 Whole-Genome Bisulfite Sequencing Data Carried Out by Broad Institute
Scientists from Broad Institute of MIT and Harvard report in-depth analysis of 42 whole-genome bisulfite sequencing data sets across 30 diverse human cell and tissue types. This study tries to answer when, where, and how many CpGs are involved in genomic regulation. Within a normal developmental context, the scientists observed dynamic regulation for only 21.8% of autosomal CpGs, most of which are situated away from transcription start sites. These dynamic CpGs co-localize with enhancers and transcription-factor-binding sites, allowing for identification [more…]
