AI Boosts Gene Editing for Epigenetic Therapies
…setting. One main reason for this lies in the risks associated with GTs. For instance, gene editing is a technique that directly alters a cell’s DNA code. If this type…
Search Results for dna methylation
HDAC Inhibitors Reduce Kidney Damage Caused by Cancer Therapy
…and DNA damage. In their study, researchers at MCG administered HDAC inhibitors (HDACis) to mice that were receiving cisplatin. Histone deacetylase inhibition is known to augment cisplatin anti-tumor inhibition, so…
Quick Tips for Validating Antibodies for Chromatin Immunoprecipitation (ChIP)
Researchers rely on high quality antibodies to perform successful chromatin immunoprecipitation (ChIP) experiments. When investigating the protein-DNA interaction of interest, valid and reliable results simply cannot be attained using nonspecific…
Could We Reverse Alzheimer’s Symptoms by Restoring Epigenetic Balance?
…to memory and learning. Histone deacetylases remove acetyl groups from histones, which tightens the chromatin structure consisting of DNA and histones. By allowing the histones to wrap the DNA more…
Exercise Training Epigenetically Benefits Overall Health
…the DNA that are bound by multiple transcription factors (TFs), and they are largely responsible for controlling gene expression by physically connecting with promoters. Enhancer regions help increase transcription, and…
Green Phytochemical Epigenetically Enhances Cancer Treatment
…activity is inhibited, it causes the relaxation of chromatin, thereby increasing accessibility to DNA and the cellular machinery responsible for gene expression. HATs modify histone tails through lysine acetylation, creating…
Epigenetic Changes May Pass Avoidance Behavior Down Multiple Generations
Science classes teach that an individual’s traits are mainly encoded in their genetic sequence—or DNA—which then gets transcribed into RNA that subsequently gets translated into the proteins that carry out…
Can Your Diet Epigenetically Shape Your Child’s Health?
…is also known as “fetal programming” or “fetal origins hypothesis.” 2,4 What is epigenetics? Epigenetics is the study of how the expression of DNA can be changed without changing the…
Epigenetic Mechanism May Promote Healthy Aging
…to repair damage done to tissues and DNA over time. But Dr. Baris Tursun from the Max Delbrück Center for Molecular Medicine (MDC) in Berlin hopes to find a way…
Parents Who Exercise Could Epigenetically Pass on Heightened Learning Ability to Their Children
…passed on to the next generation through epigenetic marks on DNA, a phenomenon called epigenetic inheritance. For example, these chemical tags could be influenced by a father’s diet, epigenetically impacting…
