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Therapeutic Targeting of Histone Modifications: Insights from the Experts

September 19, 2023 Mike Spelios

This article was first published by EpigenTek. It would be a near impossible feat for the human genome, consisting of some 3 billion bases, to fit within its relatively miniscule cellular accommodations if not for the help of a family of very critical DNA-interacting proteins. Histones are the primary protein constituent of chromatin, forming complexes with DNA to compact our rather expansive genetic material for efficient nuclear organization. But make no mistake, these protein “spools” are not merely packaging units [more…]

The Role of Epigenetics in Traditional Chinese Medicine

August 22, 2023 Natalie Crowley

Traditional Chinese medicine (TCM) has been around for thousands of years, and for good reason. It’s a holistic approach to health that can help you feel your best, both physically and mentally. But it wasn’t until recently that scientists started to uncover some of the underlying mechanisms behind its effectiveness. One such mechanism is epigenetics, which refers to changes in gene expression that can occur without alterations to the DNA sequence itself. Epigenetic changes can be influenced by a variety [more…]

Exposure to Chemicals in Plastics During Development Could Increase the Risk of Autism and Dementia

May 30, 2023 Pamela A. Harvey

Associations between prenatal exposure to chemicals like endocrine disruptors found in plastics and the development of neurological diseases later in life have been well described (1). Although mechanisms have been proposed for how endocrine disruptors affect human health (2), those mediating the development of neurological conditions like autism and dementia have been difficult to elucidate because of the multifactorial nature of these diseases. Researchers, therefore, considered the issue through a new lens: inherited DNA methylation patterns. Bisphenols and phthalates are [more…]

Living in a dreamworld: What genetics (and epigenetics?) can tell us about lucid dreams

September 13, 2022 Mike Spelios

Have you ever become aware that you’re in a dream state while you’re dreaming? If so, then chances are you’ve had a lucid dream. Much like Neo plugged into a simulated Matrix, you are cognizant of your altered reality and can even manipulate your dream environment. Lucid dreams can be quite pleasant for some people. For others, especially those with “Reward Deficiency Syndrome” (RDS) behaviors like attention deficit hyperactivity disorder, Tourette’s syndrome, post-traumatic stress disorder (PTSD), and substance use disorder [more…]

Racial Health Disparities Linked to Epigenetic Elements

February 15, 2022 Natalie Crowley

When it comes to health, race typically has an impact. Evidence compiled over several decades points out marked differences in morbidity and mortality rates across varying racial and ethnic minority groups. And while these disparities can arise from any number of environmental or social exposures, exactly how they detrimentally affect the human body and why they continue to impact certain minority groups is not entirely understood. Most findings attribute minority health disparities to inequalities in education, socioeconomic status, access to [more…]

Exercise Training Epigenetically Benefits Overall Health

September 14, 2021 Natalie Crowley

There’s no question that exercise is good for you, not only for developing a great physique but for overall health. Some would even say that regular exercise, combined with proper nutrition, is better at preventing and treating certain diseases than many pharmacological interventions. Even so, medical experts are still trying to determine exactly how physical fitness affects the chemical make-up of the body, especially regarding how it reduces the risks of developing chronic illnesses like cancer, cardiovascular disease, diabetes, and [more…]

DNA Methylation at PON3 May Lead to Weight Loss in Humans Following a Hypocaloric Diet.

March 30, 2021 Brandon Eudy

Obesity has become a major pandemic in the United States and other countries and is a major burden to healthcare costs due to its co-morbidities including cardiovascular disease, type 2 diabetes, and cancer. More effective ways to treat and prevent obesity and its related co-morbidities is a dire need currently being addressed by biomedical and nutritional sciences research. Weight gain and obesity are driven by a multitude of factors including diet, toxicant exposure, genetic background, and other lifestyle factors. An [more…]

Low-Cal Diet Could Change Epigenetic Patterns in Obesity-Related Disease

July 21, 2020 Fanni Daniella Szakal

Obesity is a disease characterized by excessive body fat. It can be caused by environment, a person’s early-life nutrition, and it can even be a result of their parent’s diet. Obesity is so dangerous because associated with many diseases such as hypertension, type-2 Diabetes, cardiovascular disease, and cancer. How does extra weight cause so many different problems? Many studies point to the fact that these diseases are, at least partially, mediated by epigenetics. In a study published in the European [more…]

Epigenetic Marks Found In Blood Test Could Help Save Diabetics

November 19, 2019 Andrea P

Type 2 diabetes is a chronic illness in which a person’s body cannot produce enough insulin to process blood sugar in a healthy way. It affects millions of people all over the world, and it can be a debilitating and even deadly disease if not properly managed. The inability to metabolize glucose can lead to long-term damage to blood vessels in organs and tissues— and may eventually lead to death. Quantifying this damage lets people take action, changing their habits and [more…]

Daytime Sleepiness May Be Result of Epigenetic Change

July 23, 2019 Andrea P

Sleep is one of the most important factors in maintaining a healthy lifestyle. For most of us, it’s our favorite activity, yet we somehow never get enough of it. Sleep deprivation can lead to weight gain, memory problems, and increased fatigue throughout the day. It turns out that feeling sleepy during the day may be a separate issue, and could be attributed to a change in a person’s epigenetics. Daytime fatigue creeping up so persistently that people can’t stay awake [more…]

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